VIP (Vasoactive Intestinal Polypeptide)
VIP (Vasoactive Intestinal Polypeptide) is a clinical biomarker on the Inflammation panel, reported in pg/mL. Standard reference range: 23–63 pg/mL. Functional (optimal) range used by integrative practitioners: 50–63 pg/mL.
What is VIP (Vasoactive Intestinal Polypeptide)?
VIP is a 28-amino acid neuropeptide produced by enteric, pulmonary (NANC), and SCN (suprachiasmatic nucleus) neurons. It is the primary endogenous NANC pulmonary vasodilator, an anti-inflammatory regulator (Th1/Th17 suppression, Treg induction), and the master coordinator of SCN-driven circadian coupling. VIP below 23 pg/mL is found in 98% of CIRS-WDB patients (N=1,829 Shoemaker case series); deficiency produces functional pulmonary hypertension, sleep dysregulation, and impaired MSH production through VPAC1/VPAC2 signaling.
Reference ranges
| Range type | Value (pg/mL) | Source |
|---|---|---|
| Standard (lab) | 23–63 | Typical Quest / LabCorp adult reference |
| Functional (optimal) | 50–63 | Integrative / functional medicine consensus |
How SomaVue interprets VIP (Vasoactive Intestinal Polypeptide)
SomaVue maps every result for VIP (Vasoactive Intestinal Polypeptide) against four clinical lenses — nutrient cofactors, toxin exposure, infection drivers, and circadian/hormonal context — and connects each interpretation to specific peer-reviewed citations. Pre-mapped clinical reasoning and cross-marker pattern detection are available inside the practitioner workspace.
See the full interpretation
Upload a patient PDF or enter values manually to see the four-lens analysis, cross-marker patterns, and cited evidence for VIP (Vasoactive Intestinal Polypeptide) and 205 other markers.
Try it freeEducational reference only. Reference ranges vary by laboratory, assay method, age, sex, and clinical context. Functional ranges represent integrative-medicine consensus and are not regulatory thresholds. SomaVue does not diagnose, treat, mitigate, or prevent disease. Always consult a licensed healthcare provider.